MESOTHELIOMA STUDY: ROLE OF MESOTHELIN GENE IN CANCER FORMATION
Senin, 03 Oktober 2016
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MESOTHELIOMA STUDY: ROLE OF MESOTHELIN GENE IN CANCER FORMATION
Mesothelioma is a rare cancer that occurs almost exclusively caused by asbestos exposure.Japanese researchers have recently investigated the mechanism of mesothelin genes that result in malignant mesothelioma. The study was published in the medical journal Human Pathology.
Mesothelioma is a rare cancer that occurs almost exclusively caused by asbestos exposure. Because there is no cure for this disease, life expectancy for most mesothelioma patients ranged between four and 18 months after diagnosis of mesothelioma sure. Although there is no cure to date, some mesothelioma patients who are diagnosed early can be given combination of aggressive therapy, such as surgery, chemotherapy and radiation. Combination therapies, known as multimodality therapy, currently has the best chance to extend the life of the patient.
The study's authors explain, "Gene methylation led to the development of malignant tumors in several tumor [malignant mesothelioma] are histologically divided into three subtypes, namely, epithelioid, sarcomatoid and biphasic type, and it showed that mesothelin expression is restricted to the type of epithelioid and biphasic epithelioid component MM type (malignant mesothelioma). However, expression regulation mechanism has not been clarified. "
Workers' high risk Pipe Asbestos Mesothelioma
A total of 118 examined lung specimens, including 39 MM, 41 lung carcinoma, 26 nonneoplastic lung lesions, and 12 samples of normal lung tissue. Specimens were tested for mesothelin expression by immunohistochemistry test, along with the methylation status of 20 locations mesothelin gene promoter.
The results showed mesothelin expressed on the part epithelioid subtype of epithelioid and biphasic subtypes. However, the expression of mesothelin is not found in either the subtype of sarcomatoid or sarcomatous part of the biphasic type. Mesothelin gene promoter had significantly hypomethylasi mesotehelioma malignant specimens without subtype when compared with other lung lesions and tissue samples of normal lung.
The risk of asbestos industry workers
The researchers concluded, "These findings suggest that hypomethylasi of mesothelin gene promoter may be specifically related to the formation of MM, regardless of the status of expression, and that expression of mesothelin protein lost in the sarcomatoid type due to some posttranscriptional regulatory mechanisms are not known. "
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